Relationship between inflammation and venous thromboembolism as studied by microparticle assessment in plasma.

nflammation and hemostasis are coupled via common ctivation pathways and feedback regulation systems. uring inflammation, the hemostatic balance may be isturbed, resulting in the increased production of prooagulant factors and in the down-regulation of anticogulant mechanisms. Thus, thrombosis promotes inflamation, which in turn stimulates a prothrombotic endency. The crosstalk between inflammation and heostasis is complex and involves enzymatic reactions, cell eceptor-mediated signaling, heterotypic cell interacions, endothelial inflammation, and the production of ell-derived microparticles, which are released into the irculation. These microparticles trigger additional celluar interactions, but their pathophysiologic effect on emostasis remains to be elucidated.